"To Thine Own Self be True" is the 621st episode of Casualty and the 31st episode of the 22nd series.
Today is Jessica's first day as a permanent nurse in Holby and also Zoe's first day as clinical lead. Meanwhile two jealous boys, Jake and Danny, fight over a girl, Karen, in the boxing ring when both of them wind their way into the ED after they brawl outside the ring. Jeff and Dixie attend a call out to a drag queen. Lou, who has collapsed after a performance and bring him into the hospital. Zoe and Maggie argue over budget cuts when Zoe tells Maggie that Ruth needs to come back into work as she is still being paid a full wage, which she would rather spend on a locum doctor. Toby was about to begin his orthopaedic rotation with Sean Anderson when it transpires that Maggie told Sean that Toby is not prepared for it. Maggie and Zoe treat Jake when they discover he has severe bruising on his back and he can no longer feel his legs. Zoe discovers the reason behind Lou's discomfort is that his liposuction site has become infected. Danny finally reveals to Jake that he has no interest in Karen as he is gay and the three friends reunite. Jessica is left distraught as Adam gets into a taxi with another woman.